PUBLISHED WORK

Research papers

  1. Preclinical Safety and Efficacy of Juvenile Cartilage-Derived Chondrocyte Sheets for Treating Focal Chondral Injury. Kondo M, Kameishi S, Kim K, Metzler NF, Maak TG, Hutchinson DT, Wang AA, Maehara M, Sato M, Grainger DW, Okano TOsteoarthritis & Cartilage (2021) Apr 01. doi:https://doi.org/10.1016/j.joca.2021.02.285

  2. Human mesenchymal stem cell sheets improve uterine incision repair in a rodent hysterotomy model. Kuramoto G, Hammad IA, Einerson BD, Allshouse AA, Debbink M, Grainger DW, Silver RM, Okano T. Am J Perinatol (2020) Dec 27. doi: 10.1055/s-0040-1721718.

  3. Femoral Head Chondrocyte Viability at the Cam Deformity in Patients with Femoroacetabular Impingement Syndrome. Rogers MJ, Kondo M, Kim K, Okano T, Maak TG. Am J Sports Med (2020) 48(14), 3586.

  4. Cell Sheets Restore Secretory Function in Wounded Mouse Submandibular Glands. Santos HTD, Kim K, Okano T, Camden J, Weisman G, Baker OJ, Nam K. Cells (2020) 9(12):2645.

  5. Fabrication of Transplantable Hyaline-like Cartilage Constructs Using Mesenchymal Stem Cell Sheets. Thorp H, Kim K, Grainger DW, Okano T. Sci Rep (2020) 10:20869.

  6. Evaluation of Multi-Layered Pancreatic Islets and Adipose-Derived Stem Cell Sheets Transplanted on Various Sites for Diabetes Treatment. Lee YN, Yi HJ, Kim YH, Lee S, Oh J, Okano T, Shim IK and Kim SC. Cells (2020), 31;9(9):E1999.

  7. Stable Cell Adhesion Affects Mesenchymal Stem Cell Sheet Fabrication: Effects of FBS and hPL. Kim K, Thorp H, Bou-Ghannam S, Grainger DW, Okano T. J Tissue Eng Regen Med (2020), 14(5):741.

  8. Rat Mesenchymal Stromal Cell Sheets Suppress Renal Fibrosis via Microvascular Protection. Imafuku A, Oka M, Miyabe Y, Sekiya S, Nitta K, Shimizu T. Stem Cells Transl Med (2019) 8:1330.

  9. Stable and Prolonged Autonomous Oscilation in a Self-Oscillating Polymer Brush Prepared on a Porous Glass Substrate. Homma K, Masuda T, Akimoto A, Nagase K, Okano T, Yoshida R. Langmuir (2019) 35(30): 9794.

  10. Phenotypic Traits of Mesenchymal Stem Cell Sheets Fabricated by Temperature-responsive Cell Culture Plate: Structural Characteristics of MSC Sheets. Nakao M, Kim K, Nagase K, Grainger DW, Kanazawa H, Okano T. Stem Cell Res Ther (2019) 10(1):353.

  11. Human Mesenchymal Stem Cell Sheets in Xeno-free Media for Possible Allogenic Applications. Kim K, Bou-Ghannam S, Thorp H, Grainger DW, Okano T. Sci Rep (2019) 9:14415.

  12. Using Cell Sheets to Regenerate Mouse Submandibular Glands. Nam K, Kim K, Dean SM, Brown CT, Davis RS, Okano T, Baker OJ. npj Regen Med (2019) 16.

  13. Engineered Mesenchymal Stemcell-sheets Patches Prevents Postoperative Pancreatic Leakage in a Rat Model. Kim SR, Yi HJ, Lee YN, Park JY, Hoffman RM, Okano T, Shim IK, Kim SC. Sci Rep (2018) 8:360.

  14. Endoscopic Transplantation of Mesenchymal Stem Cell Sheets in Experimental Colitis in Rats. Pak S, Hwang SW, Shim IK, Bae SM, Ryu YM, Kim HB, Do EJ, Son HN, Choi EJ, Park SH, Kim SY, Park SH, Ye BD, Yang SK, Kanai N, Maeda M, Okano T, Yang DH, Byeon JS, Myung SJ. Sci Rep (2018) 8:11314.

 

Review papers

  1. Strategies to address mesenchymal stem/stromal cell heterogeneity in immunomodulatory profiles to improve cell-based therapies. Dunn CM, Kameishi S, Grainger DW, Okano T. Acta Bio (2021) doi: https://doi.org/10.1016/j.actbio.2021.03.069.

  2. Capillary Networks for Bio-Artificial Three-Dimensional Tissues Fabricated Using Cell Sheet Based Tissue Engineering. Sekine H, Okano T. Int J Mol Sci (2021) 22:92.

  3. Novel Therapies Using Cell Sheets Engineered from Allogenic Mesenchymal Stem/Stromal Cells. Kondo M, Kameishi S, Grainger DW, Okano T. Emerging Topics Life Sci (2020) 4(6):677.

  4. Allogeneic Cell Sheet Therapy:A New Frontier in Drug Delivery Systems. Kim K, Bou-Ghannam S, Kameishi S, Oka M, Grainger DW, Okano T. J Control Release (2020) 330:696.

  5. Cell Sheet Tissue Engineering for Scaffold Free Three-dimensional (3D) Tissue Reconstruction. Kim K, Bou-Ghannam S, Okano T. Methods Cell Biol (2020), 157:143.

  6. Utah’s Cell Sheet Tissue Engineering Center, Kim K, Grainger DW, Okano T. Regen Ther (2019) 11: 2.

  7. Cell Sheet Tissue Engineering: Cell Sheet Preparation, Harvesting/Manipulation, and Transplantation. Kobayashi J, Kikuchi A, Aoyagi T, Okano T. J Biomed Mater Res A (2019) 107(5):955.

  8. Design of Temperature-Responsive Polymer-Grafted Surfaces for Cell Sheet Preparation and Manipulation. Kobayashi J, Okano T. Bull Chem Soc Jpn (2019) 92:817.

  9. Hepatocyte Transplantation: Cell Sheet Technology for Liver Cell Transplantation. Tatsumi K, Okano T. Curr Transpl Rep (2017) 4:184.

PATENTS

PCT application submitted 1/15/2020

HUMAN UMBILICAL CORD MESENCHYMAL STEM CELL SHEETS AND METHODS FOR THEIR PRODUCTION

Provisional patent filed 3/7/2019

SALIVARY GLAND CONSTRUCTION AND REGENERATION

PCT application submitted 1/15/2020

USE OF MESENCHYMAL STEM CELL SHEETS FOR PREVENTING UTERINE SCAR

Provisional patent filed 10/8/2019

CHONDROGENIC HMSC CELL SHEETS

Disclosure form submitted 8/7/2019 - draft in progress

POLYDACTYLY CELL SHEET/ENGINEERING CELL CONSTRUCT FOR CARTILAGE REPAIR