CSTEC@UTAH
Cell Sheet Tissue Engineering Center @ The University of Utah
OUR MISSION
The Cell Sheet Tissue Engineering Center at the University of Utah (CSTEC@Utah) was established in 2015 by Dr. Teruo Okano and Dr. David Grainger. This center represents the ongoing collaboration between the University of Utah in Salt Lake City, Utah and the Tokyo Women's Medical University and Waseda University Joint Institute of Advanced Biomedical Sciences (TWIns) in Tokyo, Japan.
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The goal of this collaborative center is to develop new allogeneic off-the-shelf cell sheet regenerative approaches in Utah for first-in-human trials and drive commercialization as a Center of Excellence to address large unmet medical needs in regenerative medicine.
​Current Applications:
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Cartilage
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Liver
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Kidney
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Uterus
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Salivary Gland
Cell sheet technology uses poly(N-isopropylacrylamide) (PIPAAm)-grafted temperature-responsive culture dishes that allow cells to spontaneously detach as confluent sheets without the damaging enzymes necessary for standard cell harvest. These cell sheets maintain the natural extracellular matrix (ECM), cell-cell junctions, and surface proteins that are broken or damaged during traditional enzymatic detachment methods and can spontaneously adhere when transplanted, ensuring localization and retention of cells at the transplantation site and negating the need for scaffold support materials. Cell sheet technology is widely applicable and has shown clinical success in regenerating a variety of tissues in vivo.
RECENTLY PUBLISHED WORK
Rapid and effective preparation of clonal bone marrow-derived mesenchymal stem/stromal cell sheets to reduce renal fibrosis
S Kameishi, CM Dunn, M Oka, K Kim, YK Cho, SU Song, DW Grainger, T Okano. Scientific Reports. 2023 Mar 17;13(1)4421 https://doi.org/10.1038/s41598-023-31437-7
Clinically relevant mesenchymal stem/stromal cell sheet transplantation method for kidney disease
Oka M, Kameishi S, Cho YK, Song SU, Grainger DW, Okano T. Tissue Engineering Part C: Methods. 2023 Feb 1;29(2):54-62. doi: 10.1089/ten.tec.2022.0200
Safety and efficacy of human juvenile chondrocyte-derived cell sheets for osteochondral defect treatment
Kondo, M., Kameishi, S., Kim, K., Metzler, N.F., Maak, T.G., Hutchinson, D.T., Wang, A.A., Maehara, M., Sato, M., Grainger, D.W., Okano, T. npj Regen Med 6, 65 (2021). https://doi.org/10.1038/s41536-021-00173-9
RESEARCH
CONTACT US
Skaggs Research Institute
(College of Pharmacy, Health Sciences campus),
Building 581,Â
30 S 2000 E, Room 2800,
Salt Lake City, UT 84112-5820